SW620 cell lines with reduced expression of CXCR3 and/or CXCR4 created using microRNA, CXCR3-, CXCR4-, and CXCR3/ CXCR4 double-knockdowns significantly reduces metastasis to lymph nodes, liver and lungs, and significantly decreases the dissemination of cancer cells to liver and lungs (16). The gene discussed is CXCR4; the disease is cancer.