CXCL12 and colorectal carcinoma: Functional CXCR4 knockdown using lentiviral short hairpin RNA (shRNA) vectors significantly decreases the migration behavior in CRC SW480 and SW620 cell lines, and pharmacologic inhibition of the SDF-1α/CXCR4 interaction by the bicyclam plerixafor at 100 μM significantly abrogates CXCR4-dependent migration and invasion (17).