CD4 and diabetes mellitus: Interestingly, the incidence of diabetes by DCs pulsed with the MHC class I and class II binding peptides gp33–41 and gp61–80 was significantly higher than that by DCs pulsed with two MHC class I peptides, gp33–41 and gp276–286, indicating that the engagement of the gp-specific CD4+ population was more effective at promoting diabetes than engagement of a second CD8+ population (Figure 5I).