In multivariable -adjusted models [model 5 (Table 4 and Table 5)], the OR for developing metabolic syndrome comparing subjects in the highest with those in the lowest quintile of baseline DPP4 activity and active GLP-1 were 2.82, 0.45 for men and 2.48, 0.36 for women respectively. The gene discussed is DPP4; the disease is metabolic syndrome.