SELE and atherosclerosis: A number of previous studies have also reported raised E-selectin in SLE, but interestingly, few have found a correlation with disease activity.4 Two small longitudinal studies found that levels of E-selectin varied little on repeated measurement even in inactive disease, suggesting that low-grade endothelial activation may persist even in the absence of significant clinical disease activity.3,4 Chronic endothelial activation may contribute to the accelerated atherosclerosis seen in SLE.