IGHG3 and neoplasm: In this regard, previous studies comparing various isotypes of mouse MoAbs for their anti-tumor effects in vivo as well as in vitro demonstrated that IgG1 showed moderate effects in vivo and in ADCC, but not in CDC, whereas IgG2a was the most effective in most cases, with IgG2b and IgG3 being variable among the reports using different sets of MoAbs and target cells [21]–[24].