To further assess the clinico-pathological relevance of our findings, nuclear netrin-1 expression (positive cells/all tumor cells) was analyzed in a multivariate Cox proportional hazard model controlling for diagnosis, patient age (in years), number of brain metastases, amount of edema (edema score) and Ki67 proliferation rate (positive cells/all tumor cells). The gene discussed is NTN1; the disease is neoplasm.