Concerning the prognostic impact of the Ki67 proliferation rate in brain metastases, univariate Kaplan-Meier survival analysis revealed a significant association of high Ki67 levels with poorer patient survival in our total cohort (Figure 4 C) while in subentities like NSCLC no significant prognostic values were found for Ki67 (Figure 4 D). This evidence concerns the gene MKI67 and non-small cell lung carcinoma.