Recently, Fang et al have reported that MKL1 mediates the deleterious effects of oxLDL, a major risk factor for atherosclerosis, by up-regulating intercellular adhesion molecule 1 (ICAM-1) transcription while simultaneously down-regulating NO synthase (eNOS) transcription in vascular endothelial cells [11]. Here, ICAM1 is linked to atherosclerosis.