With regard to the role and involvement of HsMetAP1 in cancer, Liu et al. [68] elucidated the physiological function of this enzyme in cell proliferation by studying the X-ray structure of the complex HsMetAP1/pyridine-2-carboxylic acid inhibitors [69,70], demonstrating that MetAP1 plays an important role in G2/M phase of the cell cycle. Here, METAP1 is linked to cancer.