The studies have shown that apigenin induces apoptosis in a variety of types of cells and exerts a broad range of molecular signaling effects, such as PI3K-Akt in human prostate cancer cells, ERK in RAW264.7 and isolated hepatocytes, JNK in acute carrageenan-induced paw edema and peritonitis [33], [34], [35], [36], [37], [38], [39]. Here, MAPK8 is linked to Familial prostate cancer.