Additionally, the EPC markers defined as CD34+KDR+ and CD34+KDR+CD133+ were significantly decreased in CIN patients compared to non-CIN patients (CIN vs. non-CIN, CD34+KDR+: 0.003±0.001 vs. 0.012±0.010%, P<0.001; CD34+KDR+CD133+: 0.003±0.002 vs. 0.010±0.010%, P<0.001). Here, PROM1 is linked to cervical squamous intraepithelial neoplasia.