A close investigation further found reads across six exon-intron junctions in MUC16, and the expression of MUC16 is significantly elevated in tumors (p-value = 3.98 × 10−13 after Benjamini-Hochberg correction), but the abundance of intron retention is 3.4%, smaller than 4.5%, the median abundance of up-regulated TSRGs, implying the over-expression of MUC16 in lung adenocarcinoma may be related to the below average intron retention level. The gene discussed is MUC16; the disease is lung adenocarcinoma.