CD4 and tuberculosis: In the multivariable analyses including gender, region of origin, HIV-transmission groups, CD4+ cell count and viral load as explanatory variables; risk factors of TB in patients who never started cART were: originating from Sub-Saharan Africa (Hazard ratio (HR) 4.05; 95% CI 1.87-8.78; P < 0.001), CD4+ cell coun t ≤ 200 cells/μl (HR 8.22; 95% CI 4.36-15.51; P < 0.001) and viral load ≥5 log10 copies/ml (HR 2.51; 95% CI 1.33-4.75; P = 0.005) (Table 4).