TXNIP and cancer: In a murine gastric carcinoma model in which tumors are induced via infection with Helicobacter pylori and cotreatment with N-methyl-N-nitrosourea, concomitant knock out of TXNIP resulted in increased numbers of tumors, heightened preneoplastic changes, increased percentage of malignant tumors, and elevated inflammatory marker expression compared to control mice with wild-type TXNIP expression [22].