The basis for this is that in addition to GBM induction of angiogenesis via VEGF, (1) at least some of the brain tumor vasculature derives from the transdifferentiation of tumor cells and does not depend on VEGF [34-36] and (2) PSMA induces VEGF-independent angiogenesis in pathological conditions [37]. The gene discussed is VEGFA; the disease is neoplasm.