In addition, given the known important role of PSMA in tumor angiogenesis, further describing its expression may provide a basis for research aimed at understanding; (1) how lower grade gliomas evolve to the highly angiogenic glioblastomas, and (2) how PSMA may contribute to angiogenesis and vasculogenic mimicry in glioblastomas. This evidence concerns the gene FOLH1 and central nervous system cancer.