SerpinB2 expression by, for instance, tumor-associated macrophages (TAMs) may also modulate anti-tumor immune responses, given (1) the recent evidence that macrophage SerpinB2 can modulate Th1/Th2 responses 12 and (2) the association of dysregulated SerpinB2 expression with Th1/Th2 perturbations in a number of human diseases 1. This evidence concerns the gene SERPINB2 and neoplasm.