Afatinib also inhibited phosphorylation of EGFR, ERK and Akt in NSCLC cells with the T790M mutation (Kim et al. 2012a; Köhler et al. 2012; Lee et al. 2013; Ninomiya et al. 2013; Solca et al. 2012; Takezawa et al. 2010, 2012). Here, EGFR is linked to non-small cell lung carcinoma.