EGFR and cancer: The cytotoxic effects of afatinib were selective for cancer cells with ErbB dysregulation (EC50 1.2–60 nM) as compared to non-malignant cell lines such as Hs-27 human and Balb/c3T3 mouse fibroblasts (EC50 2,835 and 2,105 nM, respectively) (Cha et al. 2012).