Originally, multiple anti-HER2 therapies ranging from therapeutic antibodies (Park et al. 1992) to antibody drug conjugates (Boyraz et al. 2013), small molecule inhibitors such as lapatinib (Hurvitz and Kakkar 2012) and liposomal vectors containing the E1A tumour suppressor known to repress the expression of HER2 as gene therapy option (Yoo et al. 2001) were simultaneously developed. The gene discussed is ERBB2; the disease is neoplasm.