Previous studies have shown diverse IFN antagonist activities mediated by NSP1 of different RV strains [37].Thus, MAVS degradation was analyzed in HT29 cells following infection with several common laboratory strains of RV namely porcine OSU, rhesus RRV, bovine A5-13 and A5-16, human Wa, KU and DS-1 (1 M.O.I.). The gene discussed is MAVS; the disease is infection.