The frequency of CIMP-high frequency in solitary CRCs observed in our study (17%) is in line with previous figures, which reinforces the accuracy of the new panel proposed by Hinoue et al. Third, in our study, there were not BRAF mutant tumors, and accordingly, the association of tumor multiplicity with a distinct methylation phenotype refers only to CIMP-high/BRAF wild-type tumors, which can represent up to 40% of CIMP-high tumors. Here, BRAF is linked to neoplasm.