Here inclusion of BMI and waist circumference in the models attenuated the associations of circulating adiponectin with insulin sensitivity, particularly in subjects without NAFLD (change of the β; OGTT: −32%, clamp: −34%), while this association was only slightly attenuated or even became stronger in the smaller group of subjects with NAFLD (OGTT: −7%, clamp: +18%). Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.