CASP1 and Sepsis: Affirming our findings above, there was a correlation between measured microvesicular caspase-1 activity from the patient and the ex vivo lymphocyte cell death induced by the patients' MVs R2 = 0.51 (p = 0.014) (Figure 3A) suggesting that caspase-1 activity is associated with the sepsis-induced lymphocyte apoptosis.