Eight cases met CDC criteria for severe CDI and the most significant predictor of severe CDI vs. non-severe CDI was an elevated IL-8 level (OR 5.92; 95% CI 1.13 – 31.1, P = .036), though eotaxin (OR 0.09, 95% CI 0.01 – 0.97, P = .047) and IL-6 (OR 3.12, 95% CI 1.05 – 9.28, P = .041) were also significant while the other 27 mediators tested were not (data not shown). This evidence concerns the gene CXCL8 and clostridium difficile infection.