CDK1 and neoplasm: Based on these findings and our results (Figure 7) as we predicted, the induction of p21, p27 and accumulation of p53 by DBDFT could cause a G2/M arrest in SGC7901 cells, which implied that p21 might inhibit the cyclin B1-CDK1 activity to promote G2/M cell cycle arrest in DBDFT treated tumor cells.