Two canonical pathways might explain the differences in cell death/survival that were reported for the LV and Lena PRRSV strains: “IL-15 production” and “Role of JAK2 in Hormone-like Cytokine Signaling”.“IL-15 production” involved five genes (IFNβ1, IL15, IRF1, JAK2 and STAT1), all of which were up-regulated following LV infection compared to Lena infection. Here, IRF1 is linked to infection.