INSIG2 and familial pancreatic carcinoma: In contrast, genes significantly increased in the control subjects include TRPC1 (Transient receptor potential cation channel, subfamily C, member 1), which is associated with a wide variety of cardiovascular diseases including neointimal hyperplasia, hypertension, atherosclerosis and hypertrophy [58], UQCRB (Ubiquinol-cytochrome c reductase binding protein), a subunit of ubiquinol-cytochrome c oxidoreductase complex involved in oxidative phosphorylation [59] and INSIG2 (Insulin-induced gene 2), which is overexpressed in a variety of colon and pancreatic cancers [60], [61].