CD4 and obesity disorder: There is increasing evidence indicating that obesity is closely related to chronic inflammation with obese adipose tissue showing some hallmarks of chronic inflammation [5], [6]; Nishimura and other authors found that large numbers of CD8+ effector T cells and macrophages infiltrated into high fat diet (HFD) mice adipose tissues, whereas the numbers of regulatory and CD4+ helper T cells were diminished [5]–[8].