AGER and medical procedure: Finally, it is also possible that the low doses (hundreds of nanograms) of radiolabeled proteins given here fail to recruit low-affinity transport receptors in the pulmonary vasculature that gain relevance when much higher doses (dozens of micrograms) of sRAGE are given i.p. or i.v. These studies are of vital importance for investigators seeking to better understand RAGE's contribution to homeostasis and pathogenesis in diseases of the lung, the organ in which RAGE is expressed most significantly.