Acute elevations in GCs are important for many biological functions; however, chronically high levels of GCs, such as those observed in patients suffering from Cushing's syndrome [7], result in unwanted metabolic disturbances such as attenuated lean tissue growth [8], increased whole body insulin resistance [9], elevated fasting glucose levels [10] and increased risk for type 2 diabetes mellitus (T2DM) development [11]–[13]. The gene discussed is INS; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.