Among the 435 studies, 56 of them were not relevant to clinical chemotherapy (only illustrating the TS expression and its clinicopathological correlation to NSCLC) and 98 of them were not relevant to NSCLCS (studying TS in small cell lung cancer, neuroendocrine, malignant pleural mesothelioma, thymic tumors, primary colorectal cancer, and so on). This evidence concerns the gene TYMS and colorectal cancer.