Among the 435 studies, 56 of them were not relevant to clinical chemotherapy (only illustrating the TS expression and its clinicopathological correlation to NSCLC) and 98 of them were not relevant to NSCLCS (studying TS in small cell lung cancer, neuroendocrine, malignant pleural mesothelioma, thymic tumors, primary colorectal cancer, and so on). Here, TYMS is linked to malignant pleural mesothelioma.