At the same time, we intended to use the nano emodin transfersome (NET) emulsion for external rubbing massage of the abdomen in a rat obesity model induced by high-fat chows to observe its weight-reduction effect and its effect on the mRNA and protein expressions of ATGL and G0S2 that regulate fat decomposition. The gene discussed is PNPLA2; the disease is obesity due to melanocortin 4 receptor deficiency.