Interestingly, 14-3-3ζ/δ is also involved in regulation of Wnt/β-catenin signaling in intestinal stem cells, a pathway that is implicated in intestinal development and regeneration [51], and that has been associated with the differentiation-promoting effect of vitamin D/VDR in colon carcinoma cells [23,52]. This evidence concerns the gene VDR and colon carcinoma.