The importance of the WNK system in controlling blood pressure was first illustrated by the finding that intronic mutations within the human WNK1 gene that increase WNK1 mRNA expression, and presumably WNK1 protein expression, result in Gordon's hypertension syndrome (also known as pseudohypoaldosteronism type II) [3,10,14]. Here, WNK1 is linked to pseudohypoaldosteronism type 2.