The NS1 antigen appears in high concentration during the first few days of illness and it stays in serum after the infection subsides i.e. up to 14 days.10,11 Beside viral antigen detection a newer approach to dengue diagnosis is the use of anti-dengue IgA based RDT devices.12 IgA is the principal secretory antibody and human serum contains very low concentration of IgA1. This evidence concerns the gene IGHA1 and dengue disease.