It has been demonstrated that single nucleated polymorphism of some genes may associate with BMD and osteoporosis, such as Collagen I and VDR.7,18 In this study, we found that polymorphism of IGF-I rs35767 was associated with increased risk of osteoporosis, and we found T allele of rs35767 had a significant lower BMD at L1–L4 vertebrae, femoral neck, total hip and trochanter when compared with those carrying C allele. The gene discussed is IGF1; the disease is osteoporosis.