Rs35767 site of IGF-1 has been shown to relate with various diseases, such as colorectal cancer, type 2 diabetes and muscle function.16 Previous studies demonstrated that IGF-1 polymorphism (rs35767) significantly associated with IGF-1 level.19 In our study, we found that IGF-I rs35767 T allele was associated with BMD and osteoporosis, which indicated that IGF-I polymorphism plays an important role in developing BMD and osteoporosis. This evidence concerns the gene IGF1 and colorectal cancer.