MTHFR and breast carcinoma: Our findings are consistent with previous studies.22-24 A meta-analysis reported no overall significant or reverse association between MTHFR C677T polymorphism and breast cancer risk, or between the MTHFR A1298C polymorphism and risk.25 Ma et al. also reported the lack of association between MTHFR C677T polymorphism and breast cancer risk in Brazilian women.4 Another meta-analysis with pooling 37 studies indicated that MTHFR 677TT variant genotype was associated with icnreased breast cancer risk.