F5 and Rare hereditary thrombophilia: Inherited thrombophilias are a heterogeneous group of coagulation disorders that predispose individuals to thrombosis, and include mutations of the factor V Leiden, prothrombin G20210A gene mutation, methylenetetrahydrofolate reductase (MTHFR) gene mutation, antithrombin III deficiency and protein C, S deficiencies (8).