Regarding ethnic differences and lack of consensus on genetic i involving in PCOS (21), we decided to conduct a study in Iranian population to compare the frequency of insulin receptor (INSR) (exon 17 and 8) and adiponectin (ADIPOQ) (exon and intron 2) genes polymorphisms between Iranian women with PCOS and normal controls. This evidence concerns the gene ADIPOQ and polycystic ovary syndrome.