In present trial the difference between two groups regarding endometrial thickness and FSH level was not significant, conversely, Fatemi et al in their trial compared dydrogestrone and natural micronized progesterone in patients with premature ovarian failure and specified significant difference regarding development of endometrial glands, serum progesterone value, LH value and FSH value (27). Here, PLOD1 is linked to primary ovarian failure.