Common among these BDNF-related disorders, such as Alzheimer's disease (AD), Huntington disease (HD), is the irregular trafficking of dense-core vesicles containing BDNF, as well as activity-dependent BDNF release from those vesicles (Gauthier et al., 2004; Chapleau et al., 2009; Poon et al., 2011). This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.