Before it was recognized as a CaCC channel, ANO1 was found to be amplified as part of human chromosome 11q13 amplicon in cancers such as esophageal squamous cell cancer (ESCC), gastrointestinal stromal tumor (GIST), head and neck squamous cell carcinoma (HNSCC), pancreatic and breast cancers 26–29. The gene discussed is ANO1; the disease is gastrointestinal stromal tumor.