The PI3K/Akt signaling pathway has frequently appeared in a variety of human cancers, such as non-small cell lung cancer (26), breast cancer (27), prostate cancer (9), ovarian cancer (28) and other physiological processes, such as epithelial-mesenchymal transition and hippocampal cell multiplication in tumor development and cancer (26,29). This evidence concerns the gene AKT1 and prostate cancer.