Rosty et al. used an Affymetrix HG-U133A oligonucleotide microarray to show that HPV E6/E7 expression plays a key role in the progression of invasive cervical cancer via the deregulation of cervical cancer proliferation cluster genes with increased average expression levels of 123 unique known genes, including RRM2 [32]. This evidence concerns the gene RRM2 and cervical cancer.