FOXP3 and infection: In E. multilocularis lesions, Foxp3 mRNA expression was increased by 2.4-fold at day 2 and by 3.0-fold at day 8 p.i. (Figure 5A); it then decreased from day 30 to day 60 p.i., and re-increased, from 1.9-fold at day 90 to 2.3-fold at day 360 p.i., with a peak of 3.1-fold at day 180, at the late stage of infection (Figure 5A), thus following a biphasic curve in the course of infection.