The contribution of the surrounding liver tissue, however, was quite significant for other ones, e.g. IL-12, IFN-γ, IL-4 and IL-17A, at the early stage of infection; CXCL9, IL-4, IL-5, CCL17, at the middle stage; and IL-10 and TGF-β at the late stage of infection. The gene discussed is IL10; the disease is infection.