FMR1 and Intellectual disability: A recent study in Drosophila shows that FMRP (fragile X mental retardation protein 1), responsible for the most common heritable form of intellectual disability, is able to modulate dADAR activity by a direct protein-protein interaction [63], with Fmr1 mutant flies showing both altered synaptic development and aberrant A-to-I RNA editing [63].