CASR and Hypocalcemia: In this regard, comparison between group 1 with hypocalcemia and group 2 without hypocalcemia revealed a large number of non-synonymous and synonymous variants that exclusively belonged to either group 1 (Table S4) or group 2 (Table S5), although the lists did not contain a c.2968A>G (p.R990G) SNP in CASR (calcium sensing receptor) that has a gain-of-function effect and appears to raise the susceptibility to hypocalcemia (Fig. S2) [20].