The pooled results indicated that IL28B rs12979860 genotype CC was not associated with hepatic steatosis (OR, 1.062; 95%CI, 0.415–2.717, P = 0.901) (Fig. 4-a), whereas rs8099917 TT was significantly associated with a lower possibility of severe steatosis (OR, 0.580; 95%CI, 0.351–0.959; P = 0.034) (Fig. 4-b). Here, IFNL3 is linked to fatty liver disease.