BRCA1 and breast cancer: Among the 1,281 hub genes, 380 (about 30% of hub genes) genes are in the breast cancer related gene set (Figure 4), including some famous breast cancer genes such as BRCA1 (Entrez gene ID: 672), BRCA2 (Entrez gene ID: 675) [42], MYC (Entrez gene ID: 4609) [43], TP53 (Entrez gene ID: 7157) [44] and BLC2 (Entrez gene ID: 596) [45].