BRCA1 and breast cancer: In the dependency network, another famous breast cancer gene BRCA1 has a significant dependency relation with gene JAK1 (Entrez ID: 3716) (with p-value of 0.0188), while BRCA1 has been reported to up-regulate JAK1 to govern cellular proliferation, differentiation, apoptosis and transformation; and all these processes are involved in breast tumorigenesis [59].