In addition, T2D risk allele G of CDC123-rs12779790 was associated with a higher fasting insulin level (β (SE) = 0.03 (0.01), P = 8.58×10−3) and a greater HOMA-IR (β (SE) = 0.04 (0.01), P = 9.39×10−3), suggesting that this locus may be involved in insulin resistance. Here, INS is linked to type 2 diabetes mellitus.