Based on this last point, we firstly asked whether the disruption of the DNMT1/PCNA/UHRF1 complex could also promote the tumor transformation of a panel of non-tumorigenic cell lines such as astrocytes (Astro#40), mammary epithelial cells (MCF10A), lung fibroblast cells (Wi38) and mesothelial cells (Met5A). This evidence concerns the gene PCNA and neoplasm.