Concerning the genes specifically hypomethylated during the tumorigenesis induced by the disruption of the DNMT1/PCNA interaction in Astro#40, MCF10A, Wi38 and Met5A cells, literature mentions the fact that the hypomethylation of the BAGE gene can be used as a biomarker for cancer detection, that Il6-induced tumorigenesis can promoted the hypomethylation of the Pax-6 gene20, 21. This evidence concerns the gene PCNA and cancer.