GGA1 and early-onset autosomal dominant Alzheimer disease: In addition, the GAT domains of human GGA1 and GGA3, but not GGA2, bind ubiquitin and ubiquitinated proteins (Shiba et al. 2004; Yogosawa et al. 2006), and GGA1 and GGA3, but not GGA2, are depleted in the brains of patients with Alzheimer disease (Walker et al. 2012).