NFE2L2 and fibrosis: To further establish the role of NRF2 rhythms in time-of-day susceptibility to bleomycin-induced fibrosis, we investigated whether the timed administration of sulforaphane (SFN; a direct NRF2 activator) can reduce the degree of bleomycin-induced fibrosis seen at the circadian nadir in NRF2 levels.